› 3v78

X-ray diffraction
2.3Å resolution

Crystal Structure of Transcriptional Regulator

Released:
DOI: 10.2210/pdb3v78/pdb
PDB entry 3v78 coloured by chain, front view.
PDB entry 3v78 coloured by chain, side view.
PDB entry 3v78 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis.
Bolla JR, Do SV, Long F, Dai L, Su CC, Lei HT, Chen X, Gerkey JE, Murphy DC, Rajashankar KR, Zhang Q, Yu EW
Nucleic Acids Res 40 9340-55 (2012)
PMID: 22821564

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161143 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 208 amino acids
Theoretical weight: 22.82 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P95092 (Residues: 1-202; Coverage: 100%)
Gene name: MT3151
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

1 bound ligand:
Ligand ET 2 x ET
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P3121
Unit cell:
a: 99.098Å b: 99.098Å c: 66.478Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.206 0.262
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

The TetR family of regulators.
Cuthbertson et al. (2013)
2 more

1 mention without citation

Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis.
Bolla et al. (2012)