EC 3.1.26.13: Retroviral ribonuclease H
Reaction catalysed:
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Systematic name:
-
Alternative Name(s):
- HIV RNase H
- RT/RNase H
- Retroviral reverse transcriptase RNaseH
GO terms
Biochemical function:
Biological process:
- negative regulation of forebrain neuron differentiation
- positive regulation of cellular senescence
- amyloid fibril formation
- positive regulation of transferrin receptor binding
- positive regulation of ferrous iron binding
- positive regulation of receptor binding
- negative regulation of receptor binding
- cellular response to nicotine
- cellular response to iron(III) ion
- cellular response to iron ion
- multicellular organismal-level iron ion homeostasis
- protein homotetramerization
- positive regulation of T cell activation
- positive regulation of immune response
- negative regulation of neurogenesis
- negative regulation of epithelial cell proliferation
- positive regulation of receptor-mediated endocytosis
- regulation of erythrocyte differentiation
- protein refolding
- regulation of iron ion transport
- T cell differentiation in thymus
- positive regulation of protein binding
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- negative regulation of neuron projection development
- learning or memory
- sensory perception of smell
- immune response
- intracellular iron ion homeostasis
- iron ion transport
- positive regulation of T cell cytokine production
- peptide antigen assembly with MHC class II protein complex
- peptide antigen assembly with MHC class I protein complex
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
- antigen processing and presentation of peptide antigen via MHC class I
- immune system process
- response to molecule of bacterial origin
- positive regulation of T cell mediated cytotoxicity
- T cell mediated cytotoxicity
Cellular component:
- HFE-transferrin receptor complex
- tertiary granule lumen
- extracellular exosome
- recycling endosome membrane
- MHC class I peptide loading complex
- MHC class II protein complex
- MHC class I protein complex
- specific granule lumen
- early endosome lumen
- late endosome membrane
- early endosome membrane
- phagocytic vesicle membrane
- membrane
- ER to Golgi transport vesicle membrane
- cell surface
- external side of plasma membrane
- focal adhesion
- plasma membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum lumen
- endoplasmic reticulum
- lysosomal membrane
- extracellular space
- extracellular region
- Golgi membrane
Sequence families
Protein families (Pfam)
InterPro annotations
IPR003006
Domain description:
Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
Occurring in:
Structure domains
CATH domains
2.60.40.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Immunoglobulins
Occurring in:
