› 3ux2

X-ray diffraction
1.8Å resolution

Crystal Structure of Domain-Swapped Fam96a Major dimer

Released:
DOI: 10.2210/pdb3ux2/pdb
PDB entry 3ux2 coloured by chain, front view.
PDB entry 3ux2 coloured by chain, side view.
PDB entry 3ux2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer.
Chen KE, Richards AA, Ariffin JK, Ross IL, Sweet MJ, Kellie S, Kobe B, Martin JL
Acta Crystallogr D Biol Crystallogr 68 637-48 (2012)
PMID: 22683786

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic iron-sulfur assembly component 2A Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H5X1 (Residues: 31-157; Coverage: 79%)
Gene names: CIA2A, CIAO2A, FAM96A
Sequence domains: Iron-sulfur cluster assembly protein

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 76.411Å b: 90.961Å c: 34.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.161 0.198
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Emerging critical roles of Fe-S clusters in DNA replication and repair.
Fuss et al. (2015)
4 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)