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Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4

X-ray diffraction
1.57Å resolution
PDB entry 3uvm coloured by chain, front view.
PDB entry 3uvm coloured by chain, side view.
PDB entry 3uvm coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: WD repeat-containing protein 5 and Histone-lysine N-methyltransferase 2B
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Multimeric state: hetero dimer
Accessible surface area: 11938.41 Å2
Buried surface area: 1442.44 Å2
Dissociation area: 721.22 Å2
Dissociation energy (ΔGdiss): 2.61 kcal/mol
Dissociation entropy (TΔSdiss): 7.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158502

Macromolecules

WD repeat-containing protein 5
Chain: A
Length: 318 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61964 (Residues: 21-334; Coverage: 94%)
Gene names: BIG3, WDR5
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
WD repeat-containing protein 5 in PDB entry 3uvm, assembly 1, front view.
WD repeat-containing protein 5 in PDB entry 3uvm, assembly 1, side view.
WD repeat-containing protein 5 in PDB entry 3uvm, assembly 1, top view.
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Histone-lysine N-methyltransferase 2B
Chain: B
Length: 10 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UMN6 (Residues: 2508-2517; Coverage: 0%)
Gene names: HRX2, KIAA0304, KMT2B, MLL2, MLL4, TRX2, WBP7
Histone-lysine N-methyltransferase 2B in PDB entry 3uvm, assembly 1, front view.
Histone-lysine N-methyltransferase 2B in PDB entry 3uvm, assembly 1, side view.
Histone-lysine N-methyltransferase 2B in PDB entry 3uvm, assembly 1, top view.
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