Function and Biology Details
Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
- not assigned
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128697 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Poly [ADP-ribose] polymerase tankyrase-1
Molecule details ›
Chains: A, B
Length: 351 amino acids
Theoretical weight: 38.24 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain
Length: 351 amino acids
Theoretical weight: 38.24 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
Q6PFX9 (Residues: 308-655; Coverage: 26%)
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain
Axin-1
Molecule details ›
Chain: C
Length: 83 amino acids
Theoretical weight: 8.78 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Axin-1 tankyrase binding domain
Length: 83 amino acids
Theoretical weight: 8.78 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
- Canonical: O35625 (Residues: 1-80; Coverage: 9%)
Sequence domains: Axin-1 tankyrase binding domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.2.2
Spacegroup:
C2
Expression system: Escherichia coli BL21
