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Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution

X-ray diffraction
1.5Å resolution
PDB entry 3us4 coloured by chain, front view.
PDB entry 3us4 coloured by chain, side view.
PDB entry 3us4 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Megakaryocyte-associated tyrosine-protein kinase
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Multimeric state: monomeric
Accessible surface area: 5568.01 Å2
Buried surface area: 391.11 Å2
Dissociation area: 79.3 Å2
Dissociation energy (ΔGdiss): 11.45 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154846
Assembly 2
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Assembly Name: Megakaryocyte-associated tyrosine-protein kinase
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Multimeric state: homo dimer
Accessible surface area: 10116.61 Å2
Buried surface area: 1794.59 Å2
Dissociation area: 506.31 Å2
Dissociation energy (ΔGdiss): -2.81 kcal/mol
Dissociation entropy (TΔSdiss): 10.82 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154847

Macromolecules

Megakaryocyte-associated tyrosine-protein kinase
Chain: A
Length: 98 amino acids
Theoretical weight: 11.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42679 (Residues: 117-213; Coverage: 19%)
Gene names: CTK, HYL, MATK
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
Megakaryocyte-associated tyrosine-protein kinase in PDB entry 3us4, assembly 1, front view.
Megakaryocyte-associated tyrosine-protein kinase in PDB entry 3us4, assembly 1, side view.
Megakaryocyte-associated tyrosine-protein kinase in PDB entry 3us4, assembly 1, top view.
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