PDBe 3ur4

X-ray diffraction
1.8Å resolution

Crystal structure of human WD repeat domain 5 with compound

Source organism: Homo sapiens
Entry authors: Dong A, Dombrovski L, Senisterra G, Wernimont A, Wasney GA, Allali Hassani A, Nguyen KT, Smil D, Bolshan Y, Hajian T, Poda G, Chau I, Al-Awar R, Bountra C, Weigelt J, Edwards AM, Arrowsmith CH, Brown P, Schapira M, Vedadi M, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 134.829Å b: 47.002Å c: 112.904Å
α: 90° β: 117.9° γ: 90°
R R work R free
0.182 0.182 0.213
Expression system: Escherichia coli BL21(DE3)