PDBe 3upa

X-ray diffraction
1.8Å resolution

A general strategy for the generation of human antibody variable domains with increased aggregation resistance

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin kappa variable 1-39 Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01597 (Residues: 23-117; Coverage: 100%)
Gene name: IGKV1-39
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 45.04Å b: 45.04Å c: 173.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.229 0.283
Expression system: Escherichia coli