PDBe 3uon

X-ray diffraction
3Å resolution

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl- D-glucosamine residues in chitodextrins. 

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; Muscarinic acetylcholine receptor M2 Chain: A
Molecule details ›
Chain: A
Length: 467 amino acids
Theoretical weight: 52.69 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08172 (Residues: 1-217, 377-466; Coverage: 66%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
  • nullnull
Gene names: CHRM2, E
Sequence domains: Phage lysozyme
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D, APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 78.17Å b: 47.26Å c: 88.12Å
α: 90° β: 109.7° γ: 90°
R-values:
R R work R free
0.227 0.225 0.276
Expression system: Spodoptera frugiperda