PDBe 3umk

X-ray diffraction
2.6Å resolution

X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble APP-beta Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 25.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 370-575; Coverage: 27%)
Gene names: A4, AD1, APP
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P43
Unit cell:
a: 39.76Å b: 39.76Å c: 126.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.206 0.239
Expression system: Escherichia coli