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Crystal structure of human Survivin K62A mutant bound to N-terminal histone H3

X-ray diffraction
2.61Å resolution
PDB entry 3uee coloured by chain, front view.
PDB entry 3uee coloured by chain, side view.
PDB entry 3uee coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Survivin homodimer complex and Histone H3.1
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Multimeric state: hetero tetramer
Accessible surface area: 17599.7 Å2
Buried surface area: 2460.17 Å2
Dissociation area: 677.93 Å2
Dissociation energy (ΔGdiss): -2.57 kcal/mol
Dissociation entropy (TΔSdiss): 11.19 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127461

Macromolecules

Baculoviral IAP repeat-containing protein 5
Chains: A, C
Length: 146 amino acids
Theoretical weight: 16.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15392 (Residues: 1-142; Coverage: 100%)
Gene names: API4, BIRC5, IAP4
Pfam: Inhibitor of Apoptosis domain
InterPro: BIR repeat
CATH: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Baculoviral IAP repeat-containing protein 5 in PDB entry 3uee, assembly 1, front view.
Baculoviral IAP repeat-containing protein 5 in PDB entry 3uee, assembly 1, side view.
Baculoviral IAP repeat-containing protein 5 in PDB entry 3uee, assembly 1, top view.
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Histone H3.1
Chains: B, D
Length: 12 amino acids
Theoretical weight: 1.31 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-13; Coverage: 9%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Histone H3.1 in PDB entry 3uee, assembly 1, front view.
Histone H3.1 in PDB entry 3uee, assembly 1, side view.
Histone H3.1 in PDB entry 3uee, assembly 1, top view.
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