PDBe 3tzi

X-ray diffraction
2.15Å resolution

X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Prostaglandin G/H synthase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 593 amino acids
Theoretical weight: 68.16 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
  • Canonical: Q05769 (Residues: 13-13, 20-604; Coverage: 99%)
Gene names: Cox-2, Cox2, Pghs-b, Ptgs2, Tis10
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: I222
Unit cell:
a: 122.265Å b: 133.508Å c: 181.093Å
α: 90° β: 90° γ: 90°
R R work R free
0.172 0.17 0.21
Expression system: Spodoptera frugiperda