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Crystal structure of the Streptomyces coelicolor WhiE ORFVI polyketide aromatase/cyclase

X-ray diffraction
1.8Å resolution
PDB entry 3tl1 coloured by chain, front view.
PDB entry 3tl1 coloured by chain, side view.
PDB entry 3tl1 coloured by chain, top view.
Source organism: Streptomyces coelicolor
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Putative polyketide cyclase
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Multimeric state: monomeric
Accessible surface area: 8640.44 Å2
Buried surface area: 486.97 Å2
Dissociation area: 106.67 Å2
Dissociation energy (ΔGdiss): 0.66 kcal/mol
Dissociation entropy (TΔSdiss): 0.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149884
Assembly 2 (preferred)
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Assembly Name: Putative polyketide cyclase
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Multimeric state: monomeric
Accessible surface area: 8415.38 Å2
Buried surface area: 294.08 Å2
Dissociation area: 147.04 Å2
Dissociation energy (ΔGdiss): 0.4 kcal/mol
Dissociation entropy (TΔSdiss): 0.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149884

Macromolecules

Putative polyketide cyclase
Chains: A, B
Length: 159 amino acids
Theoretical weight: 18.22 KDa
Source organism: Streptomyces coelicolor
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23154 (Residues: 1-159; Coverage: 100%)
Gene names: SC6G9.18, SCO5315
Pfam: Polyketide cyclase / dehydrase and lipid transport
InterPro:
CATH: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4
Putative polyketide cyclase in PDB entry 3tl1, assembly 2, front view.
Putative polyketide cyclase in PDB entry 3tl1, assembly 2, side view.
Putative polyketide cyclase in PDB entry 3tl1, assembly 2, top view.
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