› 3tk9

X-ray diffraction
2.2Å resolution

Crystal structure of human granzyme H

Released:
DOI: 10.2210/pdb3tk9/pdb
PDB entry 3tk9 coloured by chain, front view.
PDB entry 3tk9 coloured by chain, side view.
PDB entry 3tk9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif.
Wang L, Zhang K, Wu L, Liu S, Zhang H, Zhou Q, Tong L, Sun F, Fan Z
J Immunol 188 765-73 (2012)
PMID: 22156497

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Granzyme H Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 25.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20718 (Residues: 21-246; Coverage: 99%)
Gene names: CGL2, CTSGL2, GZMH
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P41212
Unit cell:
a: 63.885Å b: 63.885Å c: 142.464Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.279 0.251 0.277
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Surface loops of trypsin-like serine proteases as determinants of function.
Goettig et al. (2019)
2 more