PDBe 3tei

X-ray diffraction
2.4Å resolution

Crystal structure of human ERK2 complexed with a MAPK docking peptide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 41.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:
Ribosomal protein S6 kinase alpha-1 Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.74 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q15418 (Residues: 712-735; Coverage: 3%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 41.7Å b: 58.98Å c: 155.73Å
α: 90° β: 90° γ: 90°
R R work R free
0.199 0.197 0.235
Expression systems:
  • Escherichia coli
  • Not provided