› 3t8v

X-ray diffraction
1.8Å resolution

A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Released:
DOI: 10.2210/pdb3t8v/pdb
PDB entry 3t8v coloured by chain, front view.
PDB entry 3t8v coloured by chain, side view.
PDB entry 3t8v coloured by chain, top view.
Source organism: Plasmodium falciparum FcB1/Columbia
Primary publication:
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.
Harbut MB, Velmourougane G, Dalal S, Reiss G, Whisstock JC, Onder O, Brisson D, McGowan S, Klemba M, Greenbaum DC
Proc Natl Acad Sci U S A 108 E526-34 (2011)
PMID: 21844374

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand MG 3 x MG
Ligand BTJ 1 x BTJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 75.542Å b: 108.821Å c: 118.274Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.16 0.198
Expression system: Escherichia coli

Quick links

Citations

14 review citations

New approaches for dissecting protease functions to improve probe development and drug discovery.
Deu et al. (2012)
13 more

4 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
3 more