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Crystal structure of the beta2 adrenergic receptor-Gs protein complex

X-ray diffraction
3.2Å resolution
PDB entry 3sn6 coloured by chain, front view.
PDB entry 3sn6 coloured by chain, side view.
PDB entry 3sn6 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 59363.09 Å2
Buried surface area: 13285.28 Å2
Dissociation area: 2,711.01 Å2
Dissociation energy (ΔGdiss): -1.04 kcal/mol
Dissociation entropy (TΔSdiss): 27.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208288

Macromolecules

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Chain: A
Length: 380 amino acids
Theoretical weight: 44.37 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04896 (Residues: 1-394; Coverage: 96%)
Gene names: GNAS, GNAS1
Pfam: G-protein alpha subunit
InterPro:
CATH:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 3sn6, assembly 1, front view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 3sn6, assembly 1, side view.
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short in PDB entry 3sn6, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 351 amino acids
Theoretical weight: 38.74 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P54311 (Residues: 2-340; Coverage: 100%)
Gene name: Gnb1
Pfam: WD domain, G-beta repeat
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 3sn6, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 3sn6, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 3sn6, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 68 amino acids
Theoretical weight: 7.56 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63212 (Residues: 1-68; Coverage: 96%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
CATH: Transducin (heterotrimeric G protein), gamma chain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 3sn6, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 3sn6, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 3sn6, assembly 1, top view.
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Beta-2 adrenergic receptor; Endolysin
Chain: R
Length: 514 amino acids
Theoretical weight: 58.3 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
  • Canonical: P07550 (Residues: 29-365; Coverage: 82%)
    • nullnull
Gene names: ADRB2, ADRB2R, B2AR, E
Pfam:
InterPro:
CATH:
Beta-2 adrenergic receptor in PDB entry 3sn6, assembly 1, front view.
Beta-2 adrenergic receptor in PDB entry 3sn6, assembly 1, side view.
Beta-2 adrenergic receptor in PDB entry 3sn6, assembly 1, top view.
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Camelid antibody VHH fragment
Chain: N
Length: 138 amino acids
Theoretical weight: 15.14 KDa
Source organism: Lama glama
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
Camelid antibody VHH fragment in PDB entry 3sn6, assembly 1, front view.
Camelid antibody VHH fragment in PDB entry 3sn6, assembly 1, side view.
Camelid antibody VHH fragment in PDB entry 3sn6, assembly 1, top view.
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