3skp › Citations

Structural basis for iron piracy by pathogenic Neisseria.

Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK
Nature 483 53-8 (2012)
Related entries: 3v83, 3v89, 3v8u, 3v8x

Cited: 149 times
EuropePMC logo PMID: 22327295

Abstract

Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane. The transport system consists of TbpA, an integral outer membrane protein, and TbpB, a co-receptor attached to the cell surface; both proteins are potentially important vaccine and therapeutic targets. Two key questions driving Neisseria research are how human transferrin is specifically targeted, and how the bacteria liberate iron from transferrin at neutral pH. To address these questions, we solved crystal structures of the TbpA-transferrin complex and of the corresponding co-receptor TbpB. We characterized the TbpB-transferrin complex by small-angle X-ray scattering and the TbpA-TbpB-transferrin complex by electron microscopy. Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process.

Articles - 3skp mentioned but not cited (2)

  1. Structural basis for iron piracy by pathogenic Neisseria. Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK. Nature 483 53-58 (2012)
  2. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)


Reviews citing this publication (45)

  1. Iron in infection and immunity. Cassat JE, Skaar EP. Cell Host Microbe 13 509-519 (2013)
  2. Iron homeostasis in host defence and inflammation. Ganz T, Nemeth E. Nat Rev Immunol 15 500-510 (2015)
  3. Lactoferrin, a bird's eye view. Vogel HJ. Biochem Cell Biol 90 233-244 (2012)
  4. Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans. Caza M, Kronstad JW. Front Cell Infect Microbiol 3 80 (2013)
  5. Super-resolution in solution X-ray scattering and its applications to structural systems biology. Rambo RP, Tainer JA. Annu Rev Biophys 42 415-441 (2013)
  6. The β-barrel assembly machinery in motion. Noinaj N, Gumbart JC, Buchanan SK. Nat Rev Microbiol 15 197-204 (2017)
  7. Mycobacteria, metals, and the macrophage. Neyrolles O, Wolschendorf F, Mitra A, Niederweis M. Immunol Rev 264 249-263 (2015)
  8. Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. Radolf JD, Deka RK, Anand A, Šmajs D, Norgard MV, Yang XF. Nat Rev Microbiol 14 744-759 (2016)
  9. Recent developments in copper and zinc homeostasis in bacterial pathogens. Braymer JJ, Giedroc DP. Curr Opin Chem Biol 19 59-66 (2014)
  10. Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface. Capdevila DA, Wang J, Giedroc DP. J Biol Chem 291 20858-20868 (2016)
  11. Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy. Barber MF, Elde NC. Trends Genet 31 627-636 (2015)
  12. Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria. Wilson MM, Bernstein HD. Trends Microbiol 24 198-208 (2016)
  13. Transferrin-mediated cellular iron delivery. Luck AN, Mason AB. Curr Top Membr 69 3-35 (2012)
  14. The transferrin-iron import system from pathogenic Neisseria species. Noinaj N, Buchanan SK, Cornelissen CN. Mol Microbiol 86 246-257 (2012)
  15. Bacterial receptors for host transferrin and lactoferrin: molecular mechanisms and role in host-microbe interactions. Morgenthau A, Pogoutse A, Adamiak P, Moraes TF, Schryvers AB. Future Microbiol 8 1575-1585 (2013)
  16. Dps biomineralizing proteins: multifunctional architects of nature. Zeth K. Biochem J 445 297-311 (2012)
  17. Looks can be deceiving: recent insights into the mechanism of protein secretion by the autotransporter pathway. Bernstein HD. Mol Microbiol 97 205-215 (2015)
  18. Protein Crystallography in Vaccine Research and Development. Malito E, Carfi A, Bottomley MJ. Int J Mol Sci 16 13106-13140 (2015)
  19. Particle exposures and infections. Ghio AJ. Infection 42 459-467 (2014)
  20. Current management of iron deficiency anemia in inflammatory bowel diseases: a practical guide. Gomollón F, Gisbert JP. Drugs 73 1761-1770 (2013)
  21. Subversion of nutritional immunity by the pathogenic Neisseriae. Cornelissen CN. Pathog Dis 76 (2018)
  22. Insertion of proteins and lipopolysaccharide into the bacterial outer membrane. Botos I, Noinaj N, Buchanan SK. Philos Trans R Soc Lond B Biol Sci 372 20160224 (2017)
  23. Iron acquisition through the bacterial transferrin receptor. Pogoutse AK, Moraes TF. Crit Rev Biochem Mol Biol 52 314-326 (2017)
  24. Strategies of Intracellular Pathogens for Obtaining Iron from the Environment. Leon-Sicairos N, Reyes-Cortes R, Guadrón-Llanos AM, Madueña-Molina J, Leon-Sicairos C, Canizalez-Román A. Biomed Res Int 2015 476534 (2015)
  25. Biological Functions of the Secretome of Neisseria meningitidis. Tommassen J, Arenas J. Front Cell Infect Microbiol 7 256 (2017)
  26. Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia. Pokorzynski ND, Thompson CC, Carabeo RA. Front Cell Infect Microbiol 7 394 (2017)
  27. Intravenous iron in inflammatory bowel diseases. Gomollón F, Gisbert JP. Curr Opin Gastroenterol 29 201-207 (2013)
  28. Molecular Evolution of Transition Metal Bioavailability at the Host-Pathogen Interface. Antelo GT, Vila AJ, Giedroc DP, Capdevila DA. Trends Microbiol 29 441-457 (2021)
  29. The big BAM theory: An open and closed case? Wu R, Stephenson R, Gichaba A, Noinaj N. Biochim Biophys Acta Biomembr 1862 183062 (2020)
  30. Beware of proteins bearing gifts: protein antibiotics that use iron as a Trojan horse. Grinter R, Milner J, Walker D. FEMS Microbiol Lett 338 1-9 (2013)
  31. Neisserial surface lipoproteins: structure, function and biogenesis. Hooda Y, Shin HE, Bateman TJ, Moraes TF. Pathog Dis 75 (2017)
  32. Transition metals at the host-pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc. Neumann W, Hadley RC, Nolan EM. Essays Biochem 61 211-223 (2017)
  33. Structural insights into the transport of small molecules across membranes. Noinaj N, Buchanan SK. Curr Opin Struct Biol 27 8-15 (2014)
  34. Ton motor complexes. Ratliff AC, Buchanan SK, Celia H. Curr Opin Struct Biol 67 95-100 (2021)
  35. A holistic view of mammalian (vertebrate) cellular iron uptake. Kosman DJ. Metallomics 12 1323-1334 (2020)
  36. Iron Acquisition by Bacterial Pathogens: Beyond Tris-Catecholate Complexes. Zhang Y, Sen S, Giedroc DP. Chembiochem 21 1955-1967 (2020)
  37. Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases. Murakami Y, Saito K, Ito H, Hashimoto Y. Proc Jpn Acad Ser B Phys Biol Sci 95 198-210 (2019)
  38. Sialic acid as a target for the development of novel antiangiogenic strategies. Chiodelli P, Urbinati C, Paiardi G, Monti E, Rusnati M. Future Med Chem 10 2835-2854 (2018)
  39. The surface lipoproteins of gram-negative bacteria: Protectors and foragers in harsh environments. Cole GB, Bateman TJ, Moraes TF. J Biol Chem 296 100147 (2021)
  40. How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children. Abuga KM, Muriuki JM, Williams TN, Atkinson SH. Int J Mol Sci 21 E6976 (2020)
  41. The 'Checkmate' for Iron Between Human Host and Invading Bacteria: Chess Game Analogy. Kalidasan V, Joseph N, Kumar S, Hamat RA, Neela VK. Indian J Microbiol 58 257-267 (2018)
  42. Computational approaches for deciphering the equilibrium and kinetic properties of iron transport proteins. Abdizadeh H, Atilgan AR, Atilgan C, Dedeoglu B. Metallomics 9 1513-1533 (2017)
  43. Pirates of the haemoglobin. Akinbosede D, Chizea R, Hare SA. Microb Cell 9 84-102 (2022)
  44. Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection. Stoudenmire JL, Greenawalt AN, Cornelissen CN. Front Cell Infect Microbiol 12 1017348 (2022)
  45. Using X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization. Rodríguez I, Gautam R, Tinoco AD. Biomimetics (Basel) 6 1 (2020)

Articles citing this publication (102)

  1. A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition. Lin J, Zhang W, Cheng J, Yang X, Zhu K, Wang Y, Wei G, Qian PY, Luo ZQ, Shen X. Nat Commun 8 14888 (2017)
  2. Sequestration and scavenging of iron in infection. Parrow NL, Fleming RE, Minnick MF. Infect Immun 81 3503-3514 (2013)
  3. Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model. Melican K, Michea Veloso P, Martin T, Bruneval P, Duménil G. PLoS Pathog 9 e1003139 (2013)
  4. X-ray structure of the Yersinia pestis heme transporter HmuUV. Woo JS, Zeltina A, Goetz BA, Locher KP. Nat Struct Mol Biol 19 1310-1315 (2012)
  5. A tale of two risks: smoking, diabetes and the subgingival microbiome. Ganesan SM, Joshi V, Fellows M, Dabdoub SM, Nagaraja HN, O'Donnell B, Deshpande NR, Kumar PS. ISME J 11 2075-2089 (2017)
  6. Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host. Chen C, Noble SM. PLoS Pathog 8 e1002956 (2012)
  7. A straightforward and efficient analytical pipeline for metaproteome characterization. Tanca A, Palomba A, Pisanu S, Deligios M, Fraumene C, Manghina V, Pagnozzi D, Addis MF, Uzzau S. Microbiome 2 49 (2014)
  8. The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD. Calmettes C, Ing C, Buckwalter CM, El Bakkouri M, Chieh-Lin Lai C, Pogoutse A, Gray-Owen SD, Pomès R, Moraes TF. Nat Commun 6 7996 (2015)
  9. Gating of TonB-dependent transporters by substrate-specific forced remodelling. Hickman SJ, Cooper REM, Bellucci L, Paci E, Brockwell DJ. Nat Commun 8 14804 (2017)
  10. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Yang N, Zhang H, Zhang H, Wang M, Hao Q, Sun H. Sci Rep 2 999 (2012)
  11. Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. Frandoloso R, Martínez-Martínez S, Calmettes C, Fegan J, Costa E, Curran D, Yu RH, Gutiérrez-Martín CB, Rodríguez-Ferri EF, Moraes TF, Schryvers AB. Infect Immun 83 1030-1038 (2015)
  12. Influence of iron status on risk of maternal or neonatal infection and on neonatal mortality with an emphasis on developing countries. Brabin L, Brabin BJ, Gies S. Nutr Rev 71 528-540 (2013)
  13. C-terminal kink formation is required for lateral gating in BamA. Lundquist K, Bakelar J, Noinaj N, Gumbart JC. Proc Natl Acad Sci U S A 115 E7942-E7949 (2018)
  14. Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus. Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA. J Biol Chem 289 6728-6738 (2014)
  15. Structural basis for haem piracy from host haemopexin by Haemophilus influenzae. Zambolin S, Clantin B, Chami M, Hoos S, Haouz A, Villeret V, Delepelaire P. Nat Commun 7 11590 (2016)
  16. Unusual Synergism of Transferrin and Citrate in the Regulation of Ti(IV) Speciation, Transport, and Toxicity. Tinoco AD, Saxena M, Sharma S, Noinaj N, Delgado Y, Quiñones González EP, Conklin SE, Zambrana N, Loza-Rosas SA, Parks TB. J Am Chem Soc 138 5659-5665 (2016)
  17. All-atom 3D structure prediction of transmembrane β-barrel proteins from sequences. Hayat S, Sander C, Marks DS, Elofsson A. Proc Natl Acad Sci U S A 112 5413-5418 (2015)
  18. Structural and functional characterization of the Staphylococcus aureus virulence factor and vaccine candidate FhuD2. Mariotti P, Malito E, Biancucci M, Lo Surdo P, Mishra RP, Nardi-Dei V, Savino S, Nissum M, Spraggon G, Grandi G, Bagnoli F, Bottomley MJ. Biochem J 449 683-693 (2013)
  19. Structural and functional insights into the role of BamD and BamE within the β-barrel assembly machinery in Neisseria gonorrhoeae. Sikora AE, Wierzbicki IH, Zielke RA, Ryner RF, Korotkov KV, Buchanan SK, Noinaj N. J Biol Chem 293 1106-1119 (2018)
  20. Structural insight into the lactoferrin receptors from pathogenic Neisseria. Noinaj N, Cornelissen CN, Buchanan SK. J Struct Biol 184 83-92 (2013)
  21. Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family. Wong CT, Xu Y, Gupta A, Garnett JA, Matthews SJ, Hare SA. Nat Commun 6 10172 (2015)
  22. Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Grinter R, Josts I, Zeth K, Roszak AW, McCaughey LC, Cogdell RJ, Milner JJ, Kelly SM, Byron O, Walker D. Mol Microbiol 93 234-246 (2014)
  23. Human calprotectin affects the redox speciation of iron. Nakashige TG, Nolan EM. Metallomics 9 1086-1095 (2017)
  24. Interaction of apo-transferrin with anticancer ruthenium complexes NAMI-A and its reduced form. Mazuryk O, Kurpiewska K, Lewiński K, Stochel G, Brindell M. J Inorg Biochem 116 11-18 (2012)
  25. Large-scale Identification of N-linked Intact Glycopeptides in Human Serum using HILIC Enrichment and Spectral Library Search. Shu Q, Li M, Shu L, An Z, Wang J, Lv H, Yang M, Cai T, Hu T, Hu T, Fu Y, Yang F. Mol Cell Proteomics 19 672-689 (2020)
  26. Neisseria meningitidis subverts the polarized organization and intracellular trafficking of host cells to cross the epithelial barrier. Barrile R, Kasendra M, Rossi-Paccani S, Merola M, Pizza M, Baldari C, Soriani M, Aricò B. Cell Microbiol 17 1365-1375 (2015)
  27. Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus. Pajuelo D, Lee CT, Roig FJ, Hor LI, Amaro C. Environ Microbiol 17 2076-2089 (2015)
  28. Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein. Mosbahi K, Wojnowska M, Albalat A, Walker D. Proc Natl Acad Sci U S A 115 6840-6845 (2018)
  29. Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria. Harrison OB, Bennett JS, Derrick JP, Maiden MCJ, Bayliss CD. Microbiology (Reading) 159 1920-1930 (2013)
  30. From Homodimer to Heterodimer and Back: Elucidating the TonB Energy Transduction Cycle. Gresock MG, Kastead KA, Postle K. J Bacteriol 197 3433-3445 (2015)
  31. Structure of the bacterial plant-ferredoxin receptor FusA. Grinter R, Josts I, Mosbahi K, Roszak AW, Cogdell RJ, Bonvin AM, Milner JJ, Kelly SM, Byron O, Smith BO, Walker D. Nat Commun 7 13308 (2016)
  32. "Anion clamp" allows flexible protein to impose coordination geometry on metal ions. Wang M, Lai TP, Wang L, Zhang H, Yang N, Sadler PJ, Sun H. Chem Commun (Camb) 51 7867-7870 (2015)
  33. Beyond the Crystal Structure: Insight into the Function and Vaccine Potential of TbpA Expressed by Neisseria gonorrhoeae. Cash DR, Noinaj N, Buchanan SK, Cornelissen CN. Infect Immun 83 4438-4449 (2015)
  34. Conserved regions of gonococcal TbpB are critical for surface exposure and transferrin iron utilization. Ostberg KL, DeRocco AJ, Mistry SD, Dickinson MK, Cornelissen CN. Infect Immun 81 3442-3450 (2013)
  35. Identification of a Large Family of Slam-Dependent Surface Lipoproteins in Gram-Negative Bacteria. Hooda Y, Lai CCL, Moraes TF. Front Cell Infect Microbiol 7 207 (2017)
  36. Lactoferrin binding protein B - a bi-functional bacterial receptor protein. Ostan NK, Yu RH, Ng D, Lai CC, Pogoutse AK, Sarpe V, Hepburn M, Sheff J, Raval S, Schriemer DC, Moraes TF, Schryvers AB. PLoS Pathog 13 e1006244 (2017)
  37. The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences. Brooks CL, Arutyunova E, Lemieux MJ. Acta Crystallogr F Struct Biol Commun 70 1312-1317 (2014)
  38. Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis. Saleem M, Prince SM, Rigby SE, Imran M, Patel H, Chan H, Sanders H, Maiden MC, Feavers IM, Derrick JP. PLoS One 8 e56746 (2013)
  39. Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body. Saxena M, Loza-Rosas SA, Gaur K, Sharma S, Pérez Otero SC, Tinoco AD. Coord Chem Rev 363 109-125 (2018)
  40. Genetics. The battle for iron. Armitage AE, Drakesmith H. Science 346 1299-1300 (2014)
  41. Identification of regulatory elements that control expression of the tbpBA operon in Neisseria gonorrhoeae. Vélez Acevedo RN, Ronpirin C, Kandler JL, Shafer WM, Cornelissen CN. J Bacteriol 196 2762-2774 (2014)
  42. Patterns of structural and sequence variation within isotype lineages of the Neisseria meningitidis transferrin receptor system. Adamiak P, Calmettes C, Moraes TF, Schryvers AB. Microbiologyopen 4 491-504 (2015)
  43. Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM. Wu R, Bakelar JW, Lundquist K, Zhang Z, Kuo KM, Ryoo D, Pang YT, Sun C, White T, Klose T, Jiang W, Gumbart JC, Noinaj N. Nat Commun 12 7131 (2021)
  44. Antimicrobial Functions of Lactoferrin Promote Genetic Conflicts in Ancient Primates and Modern Humans. Barber MF, Kronenberg Z, Yandell M, Elde NC. PLoS Genet 12 e1006063 (2016)
  45. Bacteriocins active against plant pathogenic bacteria. Grinter R, Milner J, Walker D. Biochem Soc Trans 40 1498-1502 (2012)
  46. Structural change of N-glycan exposes hydrophobic surface of human transferrin. Nagae M, Morita-Matsumoto K, Arai S, Wada I, Matsumoto Y, Saito K, Hashimoto Y, Yamaguchi Y. Glycobiology 24 693-702 (2014)
  47. Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species. Fegan JE, Calmettes C, Islam EA, Ahn SK, Chaudhuri S, Yu RH, Gray-Owen SD, Moraes TF, Schryvers AB. Front Immunol 10 247 (2019)
  48. Loss of Ca2+/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease. Sabbir MG. Front Mol Biosci 5 99 (2018)
  49. Nanocrystal facet modulation to enhance transferrin binding and cellular delivery. Qi Y, Zhang T, Jing C, Liu S, Zhang C, Alvarez PJJ, Chen W. Nat Commun 11 1262 (2020)
  50. Dissection of the function of the RmpM periplasmic protein from Neisseria meningitidis. Maharjan S, Saleem M, Feavers IM, Wheeler JX, Care R, Derrick JP. Microbiology (Reading) 162 364-375 (2016)
  51. Ferric pyrophosphate citrate: interactions with transferrin. Pratt R, Handelman GJ, Edwards TE, Gupta A. Biometals 31 1081-1089 (2018)
  52. Humanized mouse model to study bacterial infections targeting the microvasculature. Melican K, Aubey F, Duménil G. J Vis Exp (2014)
  53. On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation. Wong WC, Maurer-Stroh S, Eisenhaber B, Eisenhaber F. BMC Bioinformatics 15 166 (2014)
  54. Protease-associated import systems are widespread in Gram-negative bacteria. Grinter R, Leung PM, Wijeyewickrema LC, Littler D, Beckham S, Pike RN, Walker D, Greening C, Lithgow T. PLoS Genet 15 e1008435 (2019)
  55. Transferrin receptor-1 iron-acquisition pathway - synthesis, kinetics, thermodynamics and rapid cellular internalization of a holotransferrin-maghemite nanoparticle construct. Piraux H, Hai J, Verbeke P, Serradji N, Ammar S, Losno R, Ha-Duong NT, Hémadi M, El Hage Chahine JM. Biochim Biophys Acta 1830 4254-4264 (2013)
  56. VIVO complexes with antibacterial quinolone ligands and their interaction with serum proteins. Sanna D, Ugone V, Sciortino G, Buglyó P, Bihari Z, Parajdi-Losonczi PL, Garribba E. Dalton Trans 47 2164-2182 (2018)
  57. A molecular docking study of the interactions between human transferrin and seven metallocene dichlorides. Güette-Fernández JR, Meléndez E, Maldonado-Rojas W, Ortega-Zúñiga C, Olivero-Verbel J, Parés-Matos EI. J Mol Graph Model 75 250-265 (2017)
  58. FmvB: A Francisella tularensis Magnesium-Responsive Outer Membrane Protein that Plays a Role in Virulence. Wu X, Ren G, Gunning WT, Weaver DA, Kalinoski AL, Khuder SA, Huntley JF. PLoS One 11 e0160977 (2016)
  59. A comparative, cross-species investigation of the properties and roles of transferrin- and lactoferrin-binding protein B from pathogenic bacteria. Ostan N, Morgenthau A, Yu RH, Gray-Owen SD, Schryvers AB. Biochem Cell Biol 95 5-11 (2017)
  60. Are lactoferrin receptors in Gram-negative bacteria viable vaccine targets? Chan C, Andisi VF, Ng D, Ostan N, Yunker WK, Schryvers AB. Biometals 31 381-398 (2018)
  61. Comprehensive Bioinformatic Assessments of the Variability of Neisseria gonorrhoeae Vaccine Candidates. Baarda BI, Zielke RA, Holm AK, Sikora AE. mSphere 6 e00977-20 (2021)
  62. Detailed molecular dynamics simulations of human transferrin provide insights into iron release dynamics at serum and endosomal pH. Abdizadeh H, Atilgan AR, Atilgan C. J Biol Inorg Chem 20 705-718 (2015)
  63. Effect of Ferredoxin Receptor FusA on the Virulence Mechanism of Pseudomonas plecoglossicida. He R, Wang J, Lin M, Tian J, Wu B, Tan X, Zhou J, Zhang J, Yan Q, Huang L. Front Cell Infect Microbiol 12 808800 (2022)
  64. Molecular insights into a molluscan transferrin homolog identified from disk abalone (Haliotis discus discus) evidencing its detectable role in host antibacterial defense. Herath HM, Elvitigala DA, Godahewa GI, Whang I, Lee J. Dev Comp Immunol 53 222-233 (2015)
  65. The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions. Kandler JL, Acevedo RV, Dickinson MK, Cash DR, Shafer WM, Cornelissen CN. Mol Microbiol 102 137-151 (2016)
  66. Uncovering New Pathogen-Host Protein-Protein Interactions by Pairwise Structure Similarity. Cui T, Li W, Liu L, Huang Q, He ZG. PLoS One 11 e0147612 (2016)
  67. Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts. Hose AJ, Pagani G, Karvonen AM, Kirjavainen PV, Roduit C, Genuneit J, Schmaußer-Hechfellner E, Depner M, Frei R, Lauener R, Riedler J, Schaub B, Fuchs O, von Mutius E, Divaret-Chauveau A, Pekkanen J, Ege MJ. Front Immunol 12 651709 (2021)
  68. Predicting long term cooperativity and specific modulators of receptor interactions in human transferrin from dynamics within a single microstate. Abdizadeh H, Atilgan C. Phys Chem Chem Phys 18 7916-7926 (2016)
  69. Small angle X-ray scattering and molecular dynamic simulations provide molecular insight for stability of recombinant human transferrin. Kulakova A, Indrakumar S, Sønderby P, Gentiluomo L, Streicher W, Roessner D, Frieß W, Peters GHJ, Harris P. J Struct Biol X 4 100017 (2020)
  70. Comparison of Leptospira interrogans and Leptospira biflexa genomes: analysis of potential leptospiral-host interactions. Mehrotra P, Ramakrishnan G, Dhandapani G, Srinivasan N, Madanan MG. Mol Biosyst 13 883-891 (2017)
  71. Elucidating the Interactions of Fluoxetine with Human Transferrin Employing Spectroscopic, Calorimetric, and In Silico Approaches: Implications of a Potent Alzheimer's Drug. Khan MS, Shahwan M, Shamsi A, Alhumaydhi FA, Alsagaby SA, Al Abdulmonem W, Abdullaev B, Yadav DK. ACS Omega 7 9015-9023 (2022)
  72. Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis. Yadav R, Govindan S, Daczkowski C, Mesecar A, Chakravarthy S, Noinaj N. Elife 10 e71683 (2021)
  73. Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model insect, Manduca sexta. Weber JJ, Kashipathy MM, Battaile KP, Go E, Desaire H, Kanost MR, Lovell S, Gorman MJ. Protein Sci 30 408-422 (2021)
  74. Structural rearrangement of Neisseria meningitidis transferrin binding protein A (TbpA) prior to human transferrin protein (hTf) binding. Duran GN, Özbil M. Turk J Chem 45 1146-1154 (2021)
  75. The Role of the Moraxella catarrhalis CopB Protein in Facilitating Iron Acquisition From Human Transferrin and Lactoferrin. Chan C, Ng D, Schryvers AB. Front Microbiol 12 714815 (2021)
  76. Varying iron release from transferrin and lactoferrin proteins. A laboratory experiment. Carmona F, González A, Sánchez M, Gálvez N, Cuesta R, Capdevila M, Dominguez-Vera JM. Biochem Mol Biol Educ 45 521-527 (2017)
  77. A clostripain-like protease plays a major role in generating the secretome of enterotoxigenic Bacteroides fragilis. Pierce JV, Fellows JD, Anderson DE, Bernstein HD. Mol Microbiol 115 290-304 (2021)
  78. From Constructs to Crystals - Towards Structure Determination of β-barrel Outer Membrane Proteins. Noinaj N, Mayclin S, Stanley AM, Jao CC, Buchanan SK. J Vis Exp (2016)
  79. Fungal physiology: Robbing the bank of haem iron. Philpott CC, Protchenko O. Nat Microbiol 1 16179 (2016)
  80. Identification of reduction-susceptible disulfide bonds in transferrin by differential alkylation using O(16)/O(18) labeled iodoacetic acid. Wang S, Kaltashov IA. J Am Soc Mass Spectrom 26 800-807 (2015)
  81. Quantifying In Situ Structural Stabilities of Human Blood Plasma Proteins Using a Novel Iodination Protein Stability Assay. Lin HL, James I, Hyer CD, Haderlie CT, Zackrison MJ, Bateman TM, Berg M, Park JS, Daley SA, Zuniga Pina NR, Tseng YJ, Moody JD, Price JC. J Proteome Res 21 2920-2935 (2022)
  82. The crystal structure of the TonB-dependent transporter YncD reveals a positively charged substrate-binding site. Grinter R, Lithgow T. Acta Crystallogr D Struct Biol 76 484-495 (2020)
  83. Toxic and Physiological Metal Uptake and Release by Human Serum Transferrin. Reilley DJ, Fuller JT, Nechay MR, Victor M, Li W, Ruberry JD, Mujika JI, Lopez X, Alexandrova AN. Biophys J 118 2979-2988 (2020)
  84. Transferrin Binding Protein B and Transferrin Binding Protein A2 Expand the Transferrin Recognition Range of Histophilus somni. Pogoutse AK, Moraes TF. J Bacteriol 202 e00177-20 (2020)
  85. Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe. Hayashi K, Longenecker KL, Liu YL, Faust B, Prashar A, Hampl J, Stoll V, Vivona S. Sci Rep 11 566 (2021)
  86. Extraintestinal Pathogenic Escherichia coli Utilizes Surface-Located Elongation Factor G to Acquire Iron from Holo-Transferrin. Sun Y, Wang X, Gong Q, Li J, Huang H, Xue F, Dai J, Tang F. Microbiol Spectr 10 e0166221 (2022)
  87. Flexibility of the coordination geometry at the N-site of Cu(II)2 human serum-transferrin induced by the different orientations of Arg124. Hata T, Shibata Y, Okano M, Kodera A, Ueda M, Iwamoto H, Tomida H, Iwamoto H, Hirose J. Biol Pharm Bull 38 358-364 (2015)
  88. FusB Energizes Import across the Outer Membrane through Direct Interaction with Its Ferredoxin Substrate. Wojnowska M, Walker D. mBio 11 e02081-20 (2020)
  89. Membrane directed expression in Escherichia coli of BBA57 and other virulence factors from the Lyme disease agent Borrelia burgdorferi. Robertson KE, Truong CD, Craciunescu FM, Yang JH, Chiu PL, Fromme P, Hansen DT. Sci Rep 9 17606 (2019)
  90. Mutagenesis of the Loop 3 α-Helix of Neisseria gonorrhoeae TdfJ Inhibits S100A7 Binding and Utilization. Maurakis SA, Stoudenmire JL, Rymer JK, Chazin WJ, Cornelissen CN. mBio 13 e0167022 (2022)
  91. Point Mutations in TbpA Abrogate Human Transferrin Binding in Neisseria gonorrhoeae. Greenawalt AN, Stoudenmire J, Lundquist K, Noinaj N, Gumbart JC, Cornelissen CN. Infect Immun 90 e0041422 (2022)
  92. Structural and functional insights into iron acquisition from lactoferrin and transferrin in Gram-negative bacterial pathogens. Chan C, Ng D, Fraser ME, Schryvers AB. Biometals 36 683-702 (2023)
  93. The CCP4 suite: integrative software for macromolecular crystallography. Agirre J, Atanasova M, Bagdonas H, Ballard CB, Baslé A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Mármol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JÉ, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jiménez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Malý M, McCoy AJ, McNicholas SJ, Medina A, Millán C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sánchez Rodríguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Usón I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K. Acta Crystallogr D Struct Biol 79 449-461 (2023)
  94. Analyzing protein topology based on Laguerre tessellation of a pore-traversing water network. Esque J, Sansom MSP, Baaden M, Oguey C. Sci Rep 8 13540 (2018)
  95. Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study. Troisi R, Galardo F, Ferraro G, Sica F, Merlino A. Inorg Chem 62 675-678 (2023)
  96. Experimental and Computational Insights into the Molecular Interactions between Human Transferrin and Apigenin: Implications of Natural Compounds in Targeting Neuroinflammation. Shahwan M, Anwar S, Yadav DK, Khan MS, Shamsi A. ACS Omega 8 46967-46976 (2023)
  97. Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches. Shamsi A, Shahwan M, Das Gupta D, Abdullah KM, Khan MS. Mol Neurobiol (2023)
  98. Insights from targeting transferrin receptors to develop vaccines for pathogens of humans and food production animals. Ewasechko NF, Chaudhuri S, Schryvers AB. Front Cell Infect Microbiol 12 1083090 (2022)
  99. Investigating molecular interactions between human transferrin and resveratrol through a unified experimental and computational approach: Role of natural compounds in Alzheimer's disease therapeutics. Khan MS, Furkan M, Shahwan M, Yadav DK, Anwar S, Khan RH, Shamsi A. Amino Acids 55 1923-1935 (2023)
  100. Metal piracy by Neisseria gonorrhoeae to overcome human nutritional immunity. Liyayi IK, Forehand AL, Ray JC, Criss AK. PLoS Pathog 19 e1011091 (2023)
  101. Peptide barcode of multidrug-resistant strains of Neisseria gonorrhoeae isolated from patients in Thailand. Roytrakul S, Sangprasert P, Jaresitthikunchai J, Phaonakrop N, Arpornsuwan T. PLoS One 18 e0289308 (2023)
  102. TbpBY167A-Based Vaccine Can Protect Pigs against Glässer's Disease Triggered by Glaesserella parasuis SV7 Expressing TbpB Cluster I. Ramos Prigol S, Klein R, Chaudhuri S, Paraboni Frandoloso G, Guizzo JA, Gutiérrez Martín CB, Schryvers AB, Kreutz LC, Frandoloso R. Pathogens 11 766 (2022)


Quick links