PDBe 3si7

X-ray diffraction
2.25Å resolution

The crystal structure of the NBD1 domain of the mouse CFTR protein, deltaF508 mutant

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystic fibrosis transmembrane conductance regulator Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 31.95 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26361 (Residues: 389-673; Coverage: 19%)
Gene names: Abcc7, Cftr
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4212
Unit cell:
a: 170.546Å b: 170.546Å c: 109.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.227
Expression system: Escherichia coli