› 3sa8

X-ray diffraction
1.5Å resolution

Crystal structure of wild-type HIV-1 protease in complex with KB83

Released:
DOI: 10.2210/pdb3sa8/pdb
PDB entry 3sa8 coloured by chain, front view.
PDB entry 3sa8 coloured by chain, side view.
PDB entry 3sa8 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Entry authors: Schiffer CA, Nalam MNL

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128763 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase A2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.82 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: O38732 (Residues: 1-99; Coverage: 100%)
Gene name: pol
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

3 bound ligands:
Ligand PO4 4 x PO4
Ligand ACT 2 x ACT
Ligand K83 1 x K83
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 50.731Å b: 57.739Å c: 61.769Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.193
Expression system: Escherichia coli

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