Function and Biology

Crystal structure of CD4 mutant bound to HLA-DR1

Source organism: Homo sapiens
Biochemical function: coreceptor activity
Biological process: immune response
Cellular component: membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF05790
Domain description: Immunoglobulin C2-set domain
Occurring in:
  1. T-cell surface glycoprotein CD4
1 copy of Pfam domain PF05790 (Immunoglobulin C2-set domain) in T-cell surface glycoprotein CD4 in PDB 3s5l.

PF00969
Domain description: Class II histocompatibility antigen, beta domain
Occurring in:
  1. HLA class II histocompatibility antigen, DRB1-1 beta chain
1 copy of Pfam domain PF00969 (Class II histocompatibility antigen, beta domain) in HLA class II histocompatibility antigen, DRB1-1 beta chain in PDB 3s5l.

PF00993
Domain description: Class II histocompatibility antigen, alpha domain
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
1 copy of Pfam domain PF00993 (Class II histocompatibility antigen, alpha domain) in HLA class II histocompatibility antigen, DR alpha chain in PDB 3s5l.

InterPro InterPro annotations
IPR000353
Domain description: MHC class II, beta chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR001003
Domain description: MHC class II, alpha chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
IPR014745
Domain description: MHC class II, alpha/beta chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR003598
Domain description: Immunoglobulin subtype 2
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR013151
Domain description: Immunoglobulin
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR000973
Domain description: T-cell surface antigen CD4
Occurring in:
  1. T-cell surface glycoprotein CD4
IPR008424
Domain description: Immunoglobulin C2-set
Occurring in:
  1. T-cell surface glycoprotein CD4

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
  3. T-cell surface glycoprotein CD4
1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DRB1-1 beta chain in PDB 3s5l.
2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DR alpha chain in PDB 3s5l.
4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T-cell surface glycoprotein CD4 in PDB 3s5l.
3.10.320.10
Class: Alpha Beta
Architecture: Roll
Topology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Homology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
1 copy of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DRB1-1 beta chain in PDB 3s5l.
2 copies of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DR alpha chain in PDB 3s5l.