PDBe 3s4y

X-ray diffraction
1.8Å resolution

Crystal structure of human thiamin pyrophosphokinase 1

Released:
Source organism: Homo sapiens
Entry authors: Shen L, Tempel W, Tong Y, Li Y, Walker JR, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiamin pyrophosphokinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 247 amino acids
Theoretical weight: 27.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H3S4 (Residues: 15-243; Coverage: 94%)
Gene name: TPK1
Sequence domains:
Structure domains: Thiamin pyrophosphokinase, catalytic domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 93.7Å b: 97.39Å c: 63.65Å
α: 90° β: 113.08° γ: 90°
R-values:
R R work R free
0.174 0.172 0.203
Expression system: Escherichia coli