Structure analysis

Crystal structure of CD4 mutant bound to HLA-DR1

X-ray diffraction
2.4Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: hetero tetramer
Accessible surface area: 25800 Å2
Buried surface area: 8800 Å2
Dissociation area: 600 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -48 kcal/mol
Symmetry number: 1
Assembly 2 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 25600 Å2
Buried surface area: 9400 Å2
Dissociation area: 600 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -52 kcal/mol
Symmetry number: 1

Macromolecules

Chains: C, F
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/Swine/Netherlands/L2/93(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 322-334; Coverage: 2%)
Gene name: HA

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Chains: G, H
Length: 191 amino acids
Theoretical weight: 21.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01730 (Residues: 26-203; Coverage: 41%)
Gene name: CD4
Pfam: Immunoglobulin C2-set domain
InterPro:
CATH: Immunoglobulins

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