PDBe 3s3s

X-ray diffraction
2.3Å resolution

Transglutaminase 2 in complex with a novel inhibitor

Released:
Entry authors: Lindemann I, Heine A, Klebe G

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
peptide inhibitor Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 665 Da
Source organism: synthetic construct
Expression system: Not provided
Protein-glutamine gamma-glutamyltransferase 2 Chain: A
Molecule details ›
Chain: A
Length: 694 amino acids
Theoretical weight: 78.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21980 (Residues: 2-687; Coverage: 100%)
Gene name: TGM2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P41212
Unit cell:
a: 71.439Å b: 71.439Å c: 310.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.226 0.296
Expression systems:
  • Not provided
  • Escherichia coli