PDBe 3s3j

X-ray diffraction
2.25Å resolution

Transglutaminase 2 in complex with a novel inhibitor

Entry authors: Lindemann I, Heine A, Klebe G

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptide inhibitor Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 634 Da
Source organism: synthetic construct
Expression system: Not provided
Protein-glutamine gamma-glutamyltransferase 2 Chain: A
Molecule details ›
Chain: A
Length: 694 amino acids
Theoretical weight: 78.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P21980 (Residues: 2-687; Coverage: 100%)
Gene name: TGM2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P41212
Unit cell:
a: 72.47Å b: 72.47Å c: 316.461Å
α: 90° β: 90° γ: 90°
R R work R free
0.218 0.214 0.281
Expression systems:
  • Not provided
  • Escherichia coli