PDBe 3rr3

X-ray diffraction
2.84Å resolution

Structure of (R)-flurbiprofen bound to mCOX-2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 560 amino acids
Theoretical weight: 64.34 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05769 (Residues: 18-577; Coverage: 95%)
Gene names: Cox-2, Cox2, Pghs-b, Ptgs2, Tis10
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21212
Unit cell:
a: 180.615Å b: 134.549Å c: 122.775Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.244
Expression system: Spodoptera frugiperda