› 3ros

X-ray diffraction
1.88Å resolution

Crystal structure of NAD-dependent aldehyde dehydrogenase from Lactobacillus acidophilus

Released:
DOI: 10.2210/pdb3ros/pdb
PDB entry 3ros coloured by chain, front view.
PDB entry 3ros coloured by chain, side view.
PDB entry 3ros coloured by chain, top view.
Source organism: Lactobacillus acidophilus
Entry authors: Eswaramoorthy S, Almo SC, Swaminathan S, New York Structural Genomics Research Consortium (NYSGRC)

Function and Biology Details

Reaction catalysed: 
Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177099 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 484 amino acids
Theoretical weight: 54.02 KDa
Source organism: Lactobacillus acidophilus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5FIM9 (Residues: 1-460; Coverage: 100%)
Gene names: LBA1632, ssdh
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
1 modified residue:
Ligand MSE 11 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 133Å b: 45.73Å c: 96.378Å
α: 90° β: 121.48° γ: 90°
R-values:
R R work R free
0.208 0.192 0.222
Expression system: Escherichia coli

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