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Crystal structure of hDLG1-PDZ1 complexed with APC

X-ray diffraction
2.3Å resolution
PDB entry 3rl7 coloured by chain, front view.
PDB entry 3rl7 coloured by chain, side view.
PDB entry 3rl7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Adenomatous polyposis coli protein and Disks large homolog 1
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Multimeric state: hetero dimer
Accessible surface area: 5654.77 Å2
Buried surface area: 885.19 Å2
Dissociation area: 442.59 Å2
Dissociation energy (ΔGdiss): 3.69 kcal/mol
Dissociation entropy (TΔSdiss): 6.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150352
Assembly 2 (preferred)
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Assembly Name: Adenomatous polyposis coli protein and Disks large homolog 1
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Multimeric state: hetero dimer
Accessible surface area: 5540.26 Å2
Buried surface area: 496.29 Å2
Dissociation area: 248.15 Å2
Dissociation energy (ΔGdiss): 0.1 kcal/mol
Dissociation entropy (TΔSdiss): 5.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150352
Assembly 3
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Assembly Name: Adenomatous polyposis coli protein and Disks large homolog 1
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Multimeric state: hetero dimer
Accessible surface area: 5520.8 Å2
Buried surface area: 768.1 Å2
Dissociation area: 384.05 Å2
Dissociation energy (ΔGdiss): 2.34 kcal/mol
Dissociation entropy (TΔSdiss): 6.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150352
Assembly 4
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Assembly Name: Adenomatous polyposis coli protein and Disks large homolog 1
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Multimeric state: hetero dimer
Accessible surface area: 5843.97 Å2
Buried surface area: 607.46 Å2
Dissociation area: 303.73 Å2
Dissociation energy (ΔGdiss): 0.51 kcal/mol
Dissociation entropy (TΔSdiss): 5.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150352
Assembly 5
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Assembly Name: Adenomatous polyposis coli protein and Disks large homolog 1
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Multimeric state: hetero dimer
Accessible surface area: 5050.07 Å2
Buried surface area: 738.68 Å2
Dissociation area: 369.34 Å2
Dissociation energy (ΔGdiss): 3.2 kcal/mol
Dissociation entropy (TΔSdiss): 5.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150352
Assembly 6
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Assembly Name: Adenomatous polyposis coli protein and Disks large homolog 1
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Multimeric state: hetero dimer
Accessible surface area: 5660.01 Å2
Buried surface area: 517.46 Å2
Dissociation area: 258.73 Å2
Dissociation energy (ΔGdiss): 0.19 kcal/mol
Dissociation entropy (TΔSdiss): 4.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150352

Macromolecules

Disks large homolog 1
Chains: A, B, C, D, E, F
Length: 107 amino acids
Theoretical weight: 11.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12959 (Residues: 220-317; Coverage: 11%)
Gene name: DLG1
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
Disks large homolog 1 in PDB entry 3rl7, assembly 2, front view.
Disks large homolog 1 in PDB entry 3rl7, assembly 2, side view.
Disks large homolog 1 in PDB entry 3rl7, assembly 2, top view.
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Adenomatous polyposis coli protein
Chains: G, H, I, J, K, L
Length: 11 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25054 (Residues: 2833-2843; Coverage: 0%)
Gene names: APC, DP2.5
Adenomatous polyposis coli protein in PDB entry 3rl7, assembly 2, front view.
Adenomatous polyposis coli protein in PDB entry 3rl7, assembly 2, side view.
Adenomatous polyposis coli protein in PDB entry 3rl7, assembly 2, top view.
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