PDBe 3rhx

X-ray diffraction
2.01Å resolution

Crystal structure of the catalytic domain of FGFR1 kinase in complex with ARQ 069

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 34.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P11362 (Residues: 461-765; Coverage: 38%)
Gene names: BFGFR, CEK, FGFBR, FGFR1, FLG, FLT2, HBGFR
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 208.43Å b: 57.865Å c: 65.686Å
α: 90° β: 107.22° γ: 90°
R-values:
R R work R free
0.205 0.201 0.262
Expression system: Escherichia coli BL21