PDBe 3raw

X-ray diffraction
2.09Å resolution

Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41

Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Fedorov O, King O, Debdab M, Carreaux F, Renault S, Bullock A, Muniz JRC, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Meijer L, Bazureau JP, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Dual specificity protein kinase CLK3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 381 amino acids
Theoretical weight: 44.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P49761 (Residues: 275-632; Coverage: 56%)
Gene name: CLK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 61.67Å b: 122.42Å c: 69.28Å
α: 90° β: 92.6° γ: 90°
R R work R free
0.182 0.181 0.219
Expression system: Escherichia coli BL21(DE3)