Function and Biology

Crystal Structure of Apo Caspase2

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

EC 3.4.22.55: Caspase-2

Reaction catalysed:
Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-
Systematic name:
-
Alternative Name(s):
  • CASP-2
  • Caspase-2L
  • Caspase-2S
  • ICH-1
  • NEDD-2
  • NEDD2 protein
  • Neural precursor cell expressed developmentally down-regulated protein 2

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00656
Domain description: Caspase domain
Occurring in:
  1. Caspase-2 subunit p18
  2. Caspase-2 subunit p12
The deposited structure of PDB entry 3r7s contains 2 copies of Pfam domain PF00656 (Caspase domain) in Caspase-2 subunit p18. Showing 1 copy in chain A.
The deposited structure of PDB entry 3r7s contains 2 copies of Pfam domain PF00656 (Caspase domain) in Caspase-2 subunit p12. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR015917
Domain description: Peptidase C14A, caspase catalytic domain
Occurring in:
  1. Caspase-2 subunit p18
  2. Caspase-2 subunit p12
IPR011600
Domain description: Peptidase C14, caspase domain
Occurring in:
  1. Caspase-2 subunit p18
  2. Caspase-2 subunit p12
IPR002398
Domain description: Peptidase C14 family
Occurring in:
  1. Caspase-2 subunit p18
  2. Caspase-2 subunit p12
IPR029030
Domain description: Caspase-like domain superfamily
Occurring in:
  1. Caspase-2 subunit p18
  2. Caspase-2 subunit p12
IPR002138
Domain description: Peptidase C14, caspase non-catalytic subunit p10
Occurring in:
  1. Caspase-2 subunit p12
IPR033139
Domain description: Peptidase family C14A, cysteine active site
Occurring in:
  1. Caspase-2 subunit p18
IPR016129
Domain description: Peptidase family C14A, His active site
Occurring in:
  1. Caspase-2 subunit p18
IPR001309
Domain description: Peptidase C14, p20 domain
Occurring in:
  1. Caspase-2 subunit p18

Structure domains

CATH CATH domains
3.30.70.1470
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Caspase-like
Occurring in:
  1. Caspase-2 subunit p12
The deposited structure of PDB entry 3r7s contains 2 copies of CATH domain 3.30.70.1470 (Alpha-Beta Plaits) in Caspase-2 subunit p12. Showing 1 copy in chain B.
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Caspase-2 subunit p18
The deposited structure of PDB entry 3r7s contains 2 copies of CATH domain 3.40.50.1460 (Rossmann fold) in Caspase-2 subunit p18. Showing 1 copy in chain A.