Function and Biology

Human very long half life Plasminogen Activator Inhibitor type-1

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: negative regulation of endothelial cell apoptotic process
Cellular component: peptidase inhibitor complex

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00079
Domain description: Serpin (serine protease inhibitor)
Occurring in:
  1. Plasminogen activator inhibitor 1
The deposited structure of PDB entry 3r4l contains 1 copy of Pfam domain PF00079 (Serpin (serine protease inhibitor)) in Plasminogen activator inhibitor 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023796
Domain description: Serpin domain
Occurring in:
  1. Plasminogen activator inhibitor 1
IPR023795
Domain description: Serpin, conserved site
Occurring in:
  1. Plasminogen activator inhibitor 1
IPR042185
Domain description: Serpin superfamily, domain 2
Occurring in:
  1. Plasminogen activator inhibitor 1
IPR042178
Domain description: Serpin superfamily, domain 1
Occurring in:
  1. Plasminogen activator inhibitor 1
IPR000215
Domain description: Serpin family
Occurring in:
  1. Plasminogen activator inhibitor 1
IPR036186
Domain description: Serpin superfamily
Occurring in:
  1. Plasminogen activator inhibitor 1

Structure domains

CATH CATH domains
3.30.497.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Antithrombin; Chain I, domain 2
Homology: Antithrombin, subunit I, domain 2
Occurring in:
  1. Plasminogen activator inhibitor 1
The deposited structure of PDB entry 3r4l contains 1 copy of CATH domain 3.30.497.10 (Antithrombin; Chain I, domain 2) in Plasminogen activator inhibitor 1. Showing 1 copy in chain A.
2.30.39.10
Class: Mainly Beta
Architecture: Roll
Topology: Alpha-1-antitrypsin; domain 1
Homology: Alpha-1-antitrypsin, domain 1
Occurring in:
  1. Plasminogen activator inhibitor 1
The deposited structure of PDB entry 3r4l contains 1 copy of CATH domain 2.30.39.10 (Alpha-1-antitrypsin; domain 1) in Plasminogen activator inhibitor 1. Showing 1 copy in chain A.