› 3r4l

X-ray diffraction
2.7Å resolution

Human very long half life Plasminogen Activator Inhibitor type-1

Released:
DOI: 10.2210/pdb3r4l/pdb
PDB entry 3r4l coloured by chain, front view.
PDB entry 3r4l coloured by chain, side view.
PDB entry 3r4l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure.
Jankun J, Yang J, Zheng H, Han FQ, Al-Senaidy A, Skrzypczak-Jankun E
Int J Mol Med 29 61-4 (2012)
PMID: 21947232

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 42.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P3121
Unit cell:
a: 72.007Å b: 72.007Å c: 194.481Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.209 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

The plasminogen activation system in periodontal tissue (Review).
Wyganowska-Świątkowska et al. (2014)
3 more

2 mentions without citation

Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition.
Sillen et al. (2020)
1 more