PDBe 3qyw

X-ray diffraction
1.5Å resolution

Crystal structure of ERK2 in complex with an inhibitor

Released:
Source organism: Rattus norvegicus
Primary publication:
In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.
Acta Crystallogr. D Biol. Crystallogr. 67 747-55 (2011)
PMID: 21904027

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 42.24 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63086 (Residues: 1-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 49.067Å b: 70.254Å c: 60.168Å
α: 90° β: 108.72° γ: 90°
R-values:
R R work R free
0.16 0.148 0.188
Expression system: Escherichia coli