PDBe 3qs7

X-ray diffraction
4.3Å resolution

Crystal structure of a human Flt3 ligand-receptor ternary complex

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fms-related tyrosine kinase 3 ligand Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 138 amino acids
Theoretical weight: 15.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49771 (Residues: 27-160; Coverage: 64%)
Gene name: FLT3LG
Sequence domains: flt3 ligand
Receptor-type tyrosine-protein kinase FLT3 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 423 amino acids
Theoretical weight: 48.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P36888 (Residues: 27-436; Coverage: 42%)
Gene names: CD135, FLK2, FLT3, STK1
Sequence domains: Immunoglobulin domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 103.89Å b: 146.26Å c: 105.95Å
α: 90° β: 109.66° γ: 90°
R-values:
R R work R free
0.261 0.26 0.281
Expression systems:
  • Escherichia coli
  • Homo sapiens