› 3qqi

X-ray diffraction
1.65Å resolution

Crystal structure of the HA1 receptor binding domain of H2 hemagglutinin

Released:
DOI: 10.2210/pdb3qqi/pdb
PDB entry 3qqi coloured by chain, front view.
PDB entry 3qqi coloured by chain, side view.
PDB entry 3qqi coloured by chain, top view.
Source organism: Influenza A virus (A/Japan/305/1957(H2N2))
Primary publication:
Structural characterization of an early fusion intermediate of influenza virus hemagglutinin.
Xu R, Wilson IA
J Virol 85 5172-82 (2011)
PMID: 21367895

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111764 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin Chains: A, B
Molecule details ›
Chains: A, B
Length: 219 amino acids
Theoretical weight: 24.57 KDa
Source organism: Influenza A virus (A/Japan/305/1957(H2N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C7S226 (Residues: 61-279; Coverage: 39%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin (Ha1 Chain); Chain: A; domain 1

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P1
Unit cell:
a: 38.629Å b: 62.318Å c: 66.034Å
α: 64.25° β: 80.04° γ: 72.12°
R-values:
R R work R free
0.201 0.199 0.234
Expression system: Trichoplusia ni

Quick links

Citations

19 review citations

Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion.
Hamilton et al. (2012)
18 more

3 mentions without citation

Structural Framework for Analysis of CD4+ T-Cell Epitope Dominance in Viral Fusion Proteins.
Landry et al. (2023)
2 more