PDBe 3qhr

X-ray diffraction
2.17Å resolution

Structure of a pCDK2/CyclinA transition-state mimic


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cyclin-dependent kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P24941 (Residues: 1-296; Coverage: 99%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-A2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 261 amino acids
Theoretical weight: 29.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P51943 (Residues: 163-422; Coverage: 62%)
Gene names: Ccna, Ccna2, Cyca, Cyca2
Sequence domains:
Structure domains: Cyclin-like
CDK2 substrate peptide: PKTPKKAKKL Chains: J, K, L, M
Molecule details ›
Chains: J, K, L, M
Length: 10 amino acids
Theoretical weight: 1.14 KDa

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 70.69Å b: 163.91Å c: 73.28Å
α: 90° β: 107.38° γ: 90°
R R work R free
0.18 0.179 0.21
Expression system: Escherichia coli