PDBe 3q6w

X-ray diffraction
1.75Å resolution

Structure of dually-phosphorylated MET receptor kinase in complex with an MK-2461 analog with specificity for the activated receptor


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P08581 (Residues: 1048-1348; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 42.895Å b: 64.091Å c: 111.107Å
α: 90° β: 90° γ: 90°
R R work R free
0.205 0.204 0.227
Expression system: Spodoptera frugiperda