PDBe 3q4t

X-ray diffraction
1.96Å resolution

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin

Released:

Function and Biology Details

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activin receptor type-2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 36.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27037 (Residues: 191-488; Coverage: 60%)
Gene names: ACVR2, ACVR2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6522
Unit cell:
a: 110.1Å b: 110.1Å c: 206.911Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.168 0.223
Expression system: Spodoptera frugiperda