› 3pwu

X-ray diffraction
1.9Å resolution

An immmunodominant CTL epitope from rinderpest virus presented by cattle MHC class I molecule N*01801(BoLA-A11)

Released:
DOI: 10.2210/pdb3pwu/pdb
PDB entry 3pwu coloured by chain, front view.
PDB entry 3pwu coloured by chain, side view.
PDB entry 3pwu coloured by chain, top view.
Source organisms:
Primary publication:
Two distinct conformations of a rinderpest virus epitope presented by bovine major histocompatibility complex class I N*01801: a host strategy to present featured peptides.
Li X, Liu J, Qi J, Gao F, Li Q, Li X, Zhang N, Xia C, Gao GF
J Virol 85 6038-48 (2011)
PMID: 21450819

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135109 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.8 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q95477 (Residues: 26-299; Coverage: 81%)
Gene name: LA-A11
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Hemagglutinin glycoprotein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 946 Da
Source organism: Rinderpest virus (strain RBOK)
Expression system: Not provided
UniProt:
  • Canonical: P41355 (Residues: 407-415; Coverage: 2%)
Gene name: H

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 47.913Å b: 72.044Å c: 120.771Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.23
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system.
Halabi et al. (2022)
24 other articles

9 mentions without citation

Two distinct conformations of a rinderpest virus epitope presented by bovine major histocompatibility complex class I N*01801: a host strategy to present featured peptides.
Li et al. (2011)
8 more