3pvl

X-ray diffraction
2.8Å resolution

Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans

Released:
Source organisms:
Primary publication:
Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo.
Science 331 757-60 (2011)
PMID: 21311020

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-161311 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Unconventional myosin-VIIa Chain: A
Molecule details ›
Chain: A
Length: 655 amino acids
Theoretical weight: 74.35 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P97479 (Residues: 965-1687; Coverage: 30%)
Gene names: Myo7, Myo7a
Sequence domains: MyTH4 domain
Structure domains:
pre-mRNA splicing regulator USH1G Chain: B
Molecule details ›
Chain: B
Length: 96 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q495M9 (Residues: 295-390; Coverage: 21%)
Gene names: SANS, USH1G

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 98.864Å b: 98.864Å c: 242.278Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.228 0.259
Expression system: Escherichia coli