PDBe 3ptz

X-ray diffraction
2.5Å resolution

Role of Packing Defects in the Evolution of Allostery and Induced Fit in Human UDP-Glucose Dehydrogenase.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-glucose 6-dehydrogenase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 494 amino acids
Theoretical weight: 55.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60701 (Residues: 1-494; Coverage: 100%)
Gene name: UGDH
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 6 x NAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 89.1Å b: 196.67Å c: 111.744Å
α: 90° β: 111.88° γ: 90°
R-values:
R R work R free
0.192 0.189 0.258
Expression system: Escherichia coli