PDBe 3pp0

X-ray diffraction
2.25Å resolution

Crystal Structure of the Kinase domain of Human HER2 (erbB2).


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Receptor tyrosine-protein kinase erbB-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 338 amino acids
Theoretical weight: 38.23 KDa
Source organism: Homo sapiens
Expression system: Antheraea
  • Canonical: P04626 (Residues: 703-1047; Coverage: 27%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 48.705Å b: 78.951Å c: 152.675Å
α: 90° β: 90° γ: 90°
R R work R free
0.189 0.185 0.26
Expression system: Antheraea