PDBe 3pnr

X-ray diffraction
2.6Å resolution

Structure of PbICP-C in complex with falcipain-2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PbICP-C Chain: B
Molecule details ›
Chain: B
Length: 187 amino acids
Theoretical weight: 21.24 KDa
Source organism: Plasmodium berghei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4YW59 (Residues: 189-353; Coverage: 47%)
Gene name: PB000502.02.0
Sequence domains: Chagasin family peptidase inhibitor I42
Falcipain 2 Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 27.03 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9N6S8 (Residues: 245-484; Coverage: 50%)
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P43
Unit cell:
a: 71.15Å b: 71.15Å c: 120.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.229
Expression system: Escherichia coli