PDBe 3pls

X-ray diffraction
2.24Å resolution

RON in complex with ligand AMP-PNP

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage-stimulating protein receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04912 (Residues: 1060-1357; Coverage: 22%)
Gene names: MST1R, PTK8, RON
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P41
Unit cell:
a: 98.631Å b: 98.631Å c: 45.297Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.231 0.29
Expression system: Spodoptera frugiperda