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Reverse Binding Mode of MetRD peptide complexed with c-Cbl TKB domain

X-ray diffraction
1.92Å resolution
PDB entry 3plf coloured by chain, front view.
PDB entry 3plf coloured by chain, side view.
PDB entry 3plf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: E3 ubiquitin-protein ligase CBL and peptide
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Multimeric state: hetero dimer
Accessible surface area: 14840.3 Å2
Buried surface area: 1110.24 Å2
Dissociation area: 364.77 Å2
Dissociation energy (ΔGdiss): 3.87 kcal/mol
Dissociation entropy (TΔSdiss): 5.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149763
Assembly 2 (preferred)
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Assembly Name: E3 ubiquitin-protein ligase CBL and peptide
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Multimeric state: hetero dimer
Accessible surface area: 14775.32 Å2
Buried surface area: 897.54 Å2
Dissociation area: 360.79 Å2
Dissociation energy (ΔGdiss): 4.05 kcal/mol
Dissociation entropy (TΔSdiss): 5.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149763

Macromolecules

MetRD peptide
Chains: A, C
Length: 11 amino acids
Theoretical weight: 1.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
MetRD peptide in PDB entry 3plf, assembly 2, front view.
MetRD peptide in PDB entry 3plf, assembly 2, side view.
MetRD peptide in PDB entry 3plf, assembly 2, top view.
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E3 ubiquitin-protein ligase CBL
Chains: B, D
Length: 329 amino acids
Theoretical weight: 38.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22681 (Residues: 25-351; Coverage: 36%)
Gene names: CBL, CBL2, RNF55
Pfam:
InterPro:
CATH:
E3 ubiquitin-protein ligase CBL in PDB entry 3plf, assembly 2, front view.
E3 ubiquitin-protein ligase CBL in PDB entry 3plf, assembly 2, side view.
E3 ubiquitin-protein ligase CBL in PDB entry 3plf, assembly 2, top view.
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