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Crystal structure of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDS) complex with NAD, a binary form

Source organism: Homo sapiens
Biochemical function: NAD binding
Biological process: glucose metabolic process
Cellular component: not assigned

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EC 1.2.1.12: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

Reaction catalysed:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Systematic name:
D-glyceraldehyde-3-phosphate:NAD(+) oxidoreductase (phosphorylating)
Alternative Name(s):
  • 3-phosphoglyceraldehyde dehydrogenase
  • Dehydrogenase, glyceraldehyde phosphate
  • GAPDH
  • Glyceraldehyde phosphate dehydrogenase (NAD)
  • Glyceraldehyde-3-P-dehydrogenase
  • Glyceraldehyde-3-phosphate dehydrogenase (NAD)
  • NAD-dependent glyceraldehyde phosphate dehydrogenase
  • NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
  • NADH-glyceraldehyde phosphate dehydrogenase
  • Phosphoglyceraldehyde dehydrogenase
  • Triosephosphate dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02800
Domain description: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
The deposited structure of PDB entry 3pfw contains 2 copies of Pfam domain PF02800 (Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain) in Glyceraldehyde-3-phosphate dehydrogenase, testis-specific. Showing 1 copy in chain A [auth O].

PF00044
Domain description: Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
The deposited structure of PDB entry 3pfw contains 2 copies of Pfam domain PF00044 (Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain) in Glyceraldehyde-3-phosphate dehydrogenase, testis-specific. Showing 1 copy in chain A [auth O].

InterPro InterPro annotations
IPR020831
Domain description: Glyceraldehyde/Erythrose phosphate dehydrogenase family
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
IPR020828
Domain description: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
IPR020829
Domain description: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
IPR020830
Domain description: Glyceraldehyde 3-phosphate dehydrogenase, active site
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
IPR006424
Domain description: Glyceraldehyde-3-phosphate dehydrogenase, type I
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
The deposited structure of PDB entry 3pfw contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Glyceraldehyde-3-phosphate dehydrogenase, testis-specific. Showing 1 copy in chain A [auth O].
3.30.360.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dihydrodipicolinate Reductase; domain 2
Homology: Dihydrodipicolinate Reductase; domain 2
Occurring in:
  1. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
The deposited structure of PDB entry 3pfw contains 2 copies of CATH domain 3.30.360.10 (Dihydrodipicolinate Reductase; domain 2) in Glyceraldehyde-3-phosphate dehydrogenase, testis-specific. Showing 1 copy in chain A [auth O].

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