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P38 inhibitor-bound

X-ray diffraction
2.3Å resolution
PDB entry 3p78 coloured by chain, front view.
PDB entry 3p78 coloured by chain, side view.
PDB entry 3p78 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 14
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Multimeric state: monomeric
Accessible surface area: 16972.95 Å2
Buried surface area: 736.82 Å2
Dissociation area: 368.41 Å2
Dissociation energy (ΔGdiss): -8.3 kcal/mol
Dissociation entropy (TΔSdiss): 4.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155650

Macromolecules

Mitogen-activated protein kinase 14
Chain: A
Length: 366 amino acids
Theoretical weight: 42.1 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 2-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 14 in PDB entry 3p78, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 3p78, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 3p78, assembly 1, top view.
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