PDBe 3oy3

X-ray diffraction
1.95Å resolution

Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 284 amino acids
Theoretical weight: 32.81 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00520 (Residues: 229-511; Coverage: 25%)
Gene names: Abl, Abl1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 66.471Å b: 59.988Å c: 89.439Å
α: 90° β: 97.97° γ: 90°
R-values:
R R work R free
0.22 0.22 0.266
Expression system: Escherichia coli