PDBe 3oxz

X-ray diffraction
2.2Å resolution

Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 284 amino acids
Theoretical weight: 32.8 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00520 (Residues: 229-511; Coverage: 25%)
Gene names: Abl, Abl1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 41.883Å b: 59.906Å c: 66.281Å
α: 90° β: 96.01° γ: 90°
R-values:
R R work R free
0.218 0.218 0.261
Expression system: Escherichia coli